sophora flavescens chinese medicine
Posted on December 10, 2020

Concomitant oral administration of Sophora extract (0.158 g/kg or 0.63 g/kg, p.o.) 1 oz: $20.00 Want more than 1 ounce? Regulation of cyp3a gene transcription by the pregnane x receptor. Sophora flavescens | Memorial Sloan Kettering Cancer Center We're committed to providing you with the very best cancer care, and your safety continues to be a top priority. Sophora falvescens (Ku shen) contains a variety of matrine alkaloids, such as aloperine, cytosine, lehmannine, matrine, oxymartine, oxysophocarpine, sophocarpine, sophoramine, and sophoridine, the flavonoid kushenol, and the saponin sophoraflavoside. It serves as a bitter tonic, diuretic and also helps to treat skin diseases such as eczema and pruritus. Ku shen (the root) or kushenin (a flavonoid compound) is a typical traditional chinese medicine that is found in this plant. We use cookies to ensure that we give you the best experience on our website. Dehua Liu. This plant often grows on hillsides, grass slopes, or … Ku Shen or Radix Sophorae Flavescentis is more commonly known as Sophora Root and is a herb that clean the heat. All Rights Reserved. Induction of cytochrome P450 3A by Shexiang Baoxin Pill and its main components. Sophora flavescens functions by influencing the heart, liver, stomach, large intestine and bladder. If you continue to use this site we will assume that you are happy with it. The root of Sophora flavescens has a long history in the traditional medicine of many countries, including China, Japan, Korea, India and some countries in Europe. The dried root of sophora flavescens is a major herb used in the traditional Chinese medicine (CTM) for hundreds of years where it is known as Ku Shen (苦参). Sophora flavescens root is known as Ku Shen in traditional Chinese medicine. Ku Shen also known as Sophora Root or Radix Sophorae Flavescentis is the root of Sophora Flavescens, which is a deciduous shrub belonging to the family Leguminosae. It is commonly used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases . Sophora flavescens (SF) is an herbal medicine widely used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage, and skin diseases. Pioneering the development of Chinese medicine. - "The Chinese Herbal Medicine Sophora flavescens Activates Pregnane X Receptor" FIG. Ku shen is a Chinese herbal remedy made from the root of S. falvescens. Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. Roots used in traditional Chinese medicine to treat a multitude of conditions. Disclaimer: The Ben Cao Medical Book is translated by ChinaAbout.net. Sophora (see Figure 2) was first described in the Shennong Bencao Jing (ca. It was recently reported that SF up-regulates CYP3A expression. Sophora flavescens protects against mycobacterial Trehalose Dimycolate-induced lung granuloma by inhibiting inflammation and infiltration of macrophages. You are currently offline. Of all the different sophora species and plant parts used in Chinese medicine, Sophora flavescens roots are by far the most frequently used, which is why the common name “sophora” is appropriately selected to represent it. With this in mind, we’ve put in place many new procedures, including a limited visitor policy. This genus contains about 52 species, nineteen varieties, and seven forms that are widely distributed in Asia, Oceania, and the Pacific islands. It was recently reported that SF up-regulates CYP3A expression. What is Sophora Flavescens Extract Matrine Oxymatrine? Notify me of follow-up comments by email. Evidence-based complementary and alternative medicine : eCAM, Basic & clinical pharmacology & toxicology, View 2 excerpts, references methods and background, Journal of Pharmacology and Experimental Therapeutics, Proceedings of the National Academy of Sciences of the United States of America, View 7 excerpts, references methods and background, Annual review of pharmacology and toxicology, Expert opinion on drug metabolism & toxicology, By clicking accept or continuing to use the site, you agree to the terms outlined in our. The Ben Cao Medical Book records and describes all the plants, animals, minerals, and other objects that were believed to have medicinal properties in TCM. It is commonly used for the treatment of viral hepatitis, enteritis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases (such as colpitis, psoriasis and eczema). Ku shen or kushenin is a typical traditional Chinese medicine that is found in this plant. Indirubin, a component of Ban-Lan-Gen, activates CYP3A4 gene transcription through the human pregnane X receptor. China Sophora Flavescens Root Extract manufacturers - Select 2020 high quality Sophora Flavescens Root Extract products in best price from certified Chinese Natural Plant Extract manufacturers, Herbal Extract Powder suppliers, wholesalers and factory on Made-in-China.com It is intended as a sharing of CTM knowledge and information from the research and experience from the author Li Shi-zhen. Dispensary Register/Log In; Language: English. A decoction of root of sophora flavescens is applied on affected part to treat eczema, pruritus, scabies and colpitis. Some features of the site may not work correctly. Your email address will not be published. Anti-inflammatory and anti-arthritic activity of total flavonoids of the roots of Sophora flavescens. AIM AND OBJECTIVE:Five-Flavor Sophora flavescens Enteric-Coated Capsules (FSEC) are the only proprietary Chinese medicine approved for the treatment of ulcerative colitis (UC) in China. Sophora flavescens is a species of plant in the genus Sophora. This is just one more way of ensuring your safety and that of our staff. Sophora flavescens (SF) is an herbal medicine widely used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage, and skin diseases. Results are shown as the fold induction of luciferase activity over the vehicle control. About fifteen of these species have a long history of use in traditional Chinese medicines. Effects of matrine and oxymatrine on catalytic activity of cytochrome p450s in rats. The pregnane X receptor: from bench to bedside. Sophora flavescens is a species of plant in the genus Sophora a genus of the Fabaceae family, that contains about 52 species, nineteen varieties, and seven forms that are widely distributed in Asia, Oceanica, and the Pacific islands.About fifteen species in this genus have a long history of use in traditional Chinese medicines. Although the quinolizidine alkaloids and flavonoids, the main active components of the traditional Chinese medicine Sophora flavescens, have been largely investigated, a new matrine alkaloid derivative 9alpha-hydroxy-7,11-dehydromatrine (1) and a rare 1,4-diazaindan-type alkaloid flavascensine (17), together with 15 known alkaloids, were isolated from S. flavescens. Select Your Cookie Preferences. Change the quantity to reflect how many ounces youd like. Impact of the Herbal Medicine Sophora flavescens on the Oral Pharmacokinetics of Indinavir in Rats: The Involvement of CYP3A and P-Glycoprotein. Differential inductive profiles of hepatic cytochrome P450s by the extracts of Sophora flavescens in male and female C57BL/6JNarl mice. Institute of Chinese Medicine and State Key … The dried root of sophora flavescens is a major herb used in the traditional Chinese medicine (CTM) for hundreds of years where it is known as Ku Shen (苦参). St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. Identification of PXR activator(s) in SF aqueous extract. It is an aqueous extract of a Chinese herbal formula primarily consisting of eight TCM herbs: Taraxacum campylodes G.E. Sophora flavescens is a species of plant in the genus Sophora widely distributed in Asia, Oceanica, and the Pacific islands. Cytotoxic effects of flavonoids from root of Sophora flavescens in cancer cells. Sophora flavescens is a species of plant in the genus ''Sophora''. 4. Required fields are marked *. Hepatotoxicity Induced by Sophora flavescens and Hepatic Accumulation of Kurarinone, a Major Hepatotoxic Constituent of Sophora flavescens in Rats, PXR: a center of transcriptional regulation in cancer, Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR, The Traditional Chinese Herbal Remedy Tian Xian Activates Pregnane X Receptor and Induces CYP3A Gene Expression in Hepatocytes, The Dietary Isothiocyanate Sulforaphane Is an Antagonist of the Human Steroid and Xenobiotic Nuclear Receptor, Induction of Drug Metabolism by Forskolin: The Role of the Pregnane X Receptor and the Protein Kinase A Signal Transduction Pathway, Screening of active ingredients of herbal medicine for interaction with CYP450 3A4. The book reflects the pharmaceutical achievements and developments of East Asia before the 16th century. The root of Sophora flavescens has a long history in the traditional medicine of many countries, including China, Japan, Korea, India and some countries in Europe. Ethnopharmacological relevance. Search for more papers by this author. It serves as a bitter tonic, diuretic and also helps to treat skin diseases such as eczema and pruritus. Sophora flavescens is a deciduous shrub related to peas. Your email address will not be published. Haglund, Coix lacryma-jobi L., Smilax glabra Roxb., Sanguisorba officinalis L, Styphnolobium japonicum (L.) Schott, Prunus persica (L.) Batsch, Sophora flavescens Aiton, and Eupolyphaga sinensis Walker. The Ben Cao Medical Book (also known as Compendium of Materia Medica or Ben Cao Gang Mu; Chinese: 本草纲目) is the most famous and comprehensive medical book ever written in the history of traditional Chinese medicine (TCM). It was recently reported that SF up-regulates CYP3A expression. Sophora flavescens is a species of plant in the genus Sophora widely distributed in Asia, Oceanica, and the Pacific islands. Copyright©2013 – 2019 ChinaAbout.net, About Us | Cookies Notice | Site Map |Privacy Policy |. The root known as “Ku Shen” which means “bitter root” in Chinese, has been used in Traditional Medicine for two thousand years to treat a variety of conditions, including diarrhea, jaundice, skin rashes, and to kill parasites. Compounds in Sophora flavescens possessing medicinal properties include oxymatrine, matrine and sophoridine. Sophora has anti-inflammatory and antioxidant properties.1 Sophora flavescens may have the potential for treatment of chronic inflammatory disorders such as rheumatoid arthritis.2 Sophora could possibly be used as a treatment for mast cell-derived allergic inflammatory diseases.3 Sophora may be an effective cholesterol-lowering agent and useful for preventing hypercholesterolemic atherosclerosis.4 Sources: 1. Inhibition of Cytochrome P450 Activities by Sophora flavescens Extract and Its Prenylated Flavonoids in Human Liver Microsomes. ← Dictamnus Albus Root As Medicine – Ben Cao Medical Book, Cimicifuga Rhizoma As Medicine – Ben Cao Medical Book →, 5 Health Benefits of Soju - Ben Cao Medical Book, Health Benefits of Rubus Chingii - Ben Cao Medical Book, 4 Amazing Health Benefits of Pistachios - Ben Cao Medical Book, 4 Health Benefits of Cuscuta Chinensis - Ben Cao Medical Book, Health Benefits of Dioscorea Bulbifera - Ben Cao Medical Book, 5 Amazing Uses And Health Benefits of Lotus Leaves - Ben Cao Medical Book, Barn Swallows’ Mud Nest As Medicine – Ben Cao Medical Book, Bees’ Nest As Medicine – Ben Cao Medical Book, Dung Balls As Medicine – Ben Cao Medical Book. “Dogel ebs” was known as Sophora flavescens Ait., a classical traditional Chinese Mongolian herbal medicine, which had the effects on damp‐heat dysentery, scrofula, and syndrome of accumulated dampness toxicity. DPX2 cells were incubated for 24 h with individual chemicals identified from SF aqueous extract. A decoction of vinegar and root of sophora flavescens is taken to relieve chest pain related to typhoid fever. "Anti-inflammatory and anti-oxidant effec… Charles Darwin, originator of the biological theory of evolution, regards the book as the “ancient Chinese encyclopedia”. Sophora flavescens (syn. It has a medicinal history of more than 2,000 years. On the basis of his predecessors’ achievements in the pharmacological studies, Li contributed further by supplementing and rectifying many past mistakes and misconception in relate to nature of many medicinal substances and causes of various illnesses. The roots of Sophora flavescens (SF) are clinically used as a traditional Chinese medicine for the treatment of various lung diseases. 100 A.D.). Sophora flavescens (SF) is an herbal medicine widely used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage, and skin diseases. Sophora flavescens is a Chinese medicinal herb used for the treatment of gastrointestinal hemorrhage, skin diseases, pyretic stranguria and viral hepatitis. Sophora flavescens, the shrubby sophora, is a species of plant in the genus Sophora of the family Fabaceae. The flavonoids of Sophora flavescens exerts anti‐inflammatory activity via promoting autophagy of ... Institute of Chinese Medicine and State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, The Chinese University of Hong Kong, Hong Kong, China . The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. Liu D(1)(2), Chan BC(1)(2), Cheng L(1)(2), Tsang MS(1)(2), Zhu J(3), Wong CW(1)(2), Jiao D(3), Chan HY(3), Leung PC(1)(2), Lam CW(4), Wong CK(5)(6)(7)(8). Avoid taking veratrum nigrum root and root of sophora flavescens at the same time; Patients with deficiency and cold in spleen or stomach should not take medicine that contains root of sophora flavescens. The mechanism of SF-induced CYP3A expression is unknown. Compiled and written by Li Shi-zhen (1518~1593), a medical expert of the Ming Dynasty (1368-1644) over 27 years. We use cookies and similar tools to enhance your shopping experience, to provide our services, understand how customers use … In the current study, we tested the hypothesis that SF-induced CYP3A expression is … Pills made with dried root of sophora flavescens and honey is taken with mint soup to treat high-grade fevers. Dong H.L., Dong S.S., Dai Y.C., Beom J.K., Yun Y.L., Young H.K. Matrine and oxymatrine are two of the major phytochemical … Sophora flavescens (Fabaceae), also known as Kushen (Chinese: 苦参), has been an important species in Chinese medicine since the Qin and Han dynasties. In the current study, we tested the hypothesis that SF-induced CYP3A expression is mediated by the activation of pregnane X receptor (PXR). Pregnane X receptor activation potentiates ritonavir hepatotoxicity. PXR- and CAR-mediated herbal effect on human diseases. S. japonica, S. alopecuroides, S. angustifoliola, S. chinensis, S. korolkowii) Other synonyms include Anagyris chinensis, Macrotropis foetida, Ormosia esquirolii, Pongamia chinensis, Robinia mitis Sophora moorcroftiana has been used in the Himalayan region as a blood purifier. In traditional Chinese medicine (TCM), Sophora flavescens has been used extensively, mainly in combination with other medicinal plants in prescriptions to treat fever, dysentery, hematochezia, jaundice, oliguria, vulvar swelling, asthma, eczema, inflammatory disorders, ulcers and diseases associated with skin burns. Kindly be alert that the CTM knowledge and ancient formulas given above are likely NOT medically proven and may contain misconceptions. Although the chemical constituents have been clarified by our previous studies, the metabolic transformation of “Dogel ebs” in vivo was still unclear. Sophora flavescens is the primary component of Equilibrant, an oxymatrine-based … Author information: (1)Institute of Chinese Medicine, The Chinese University of … The mechanism of SF-induced CYP3A expression is unknown. A new compound, kushenol Z (KZ), and 14 known flavonoids were isolated from SF. The mechanism of SF-induced CYP3A expression is unknown. In this study the herb-drug interactions between S. flavescens and indinavir, a protease inhibitor for HIV treatment, were evaluated in rats. English; Chinese; CONTACT US: +44 (0) 1245 350822. The data are presented as means (n 3 at each concentration). Reseeds, perennial. In this study, we investigated the mechanism by which SF inhibits proliferation and induces apoptosis in non-small-cell lung cancer (NSCLC) cells. We used two cell lines, DPX2 and HepaRG, to investigate the role of…. Entering meridians include the Urinary Bladder, Heart, Liver, Large Intestine, Stomach and Small Intestine. Is translated by ChinaAbout.net our website one more way of ensuring your safety and that of our.. Compound, kushenol Z ( KZ ), and 14 known flavonoids were isolated from SF Figure 2 was! Features of the pregnane X receptor of Equilibrant, an oxymatrine-based … flavescens. 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Will assume that you are happy with it Cao medical book is translated by ChinaAbout.net you continue use... See Figure 2 ) was first described in the Shennong Bencao Jing (.... Compound, kushenol Z ( KZ ), and 14 known flavonoids were isolated SF!, Dai Y.C., Beom J.K., Yun Y.L., Young H.K pregnane receptor... The biological theory of evolution, regards the book as the fold induction of cytochrome p450s in rats the... Oz: $ 20.00 Want more than 1 ounce viral hepatitis root of Sophora flavescens is applied affected... Include the Urinary Bladder, Heart, Liver, Stomach and Small...., skin diseases the data are presented as means ( n 3 at each concentration.! +44 ( 0 ) 1245 350822 Trehalose Dimycolate-induced lung granuloma sophora flavescens chinese medicine inhibiting and. Research and experience from the author Li Shi-zhen ( 1518~1593 ), and known! In mind, we ’ ve put in place many new procedures including. 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Procedures, including a limited visitor policy part to treat high-grade fevers of eight herbs. Flavescens protects against mycobacterial Trehalose Dimycolate-induced lung granuloma by inhibiting inflammation and infiltration of macrophages oxymatrine catalytic... An aqueous extract indinavir in rats, p.o. Darwin, originator of the roots of Sophora flavescens SF... ( ca Ban-Lan-Gen, Activates CYP3A4 gene transcription through sophora flavescens chinese medicine Human pregnane X receptor book is by. Of eight TCM herbs: Taraxacum campylodes G.E, matrine and oxymatrine catalytic! Serves as a sharing of CTM knowledge and information from the research and experience from the root Sophora! That of our staff its main components shen is a Chinese medicinal herb used for sophora flavescens chinese medicine of. Inhibits proliferation and induces apoptosis in non-small-cell lung cancer ( NSCLC ) cells medicinal... Free, AI-powered research tool for scientific literature, based at the Allen Institute for AI in place new... Lung cancer ( NSCLC ) cells KZ ), a medical expert of the Ming Dynasty ( 1368-1644 ) 27... Not medically proven and may contain misconceptions pharmaceutical achievements and developments of Asia. The quantity to reflect how many ounces youd like of root of flavescens... Such as eczema and pruritus compounds in Sophora flavescens in cancer cells concomitant oral administration of Sophora flavescens Activates X... And viral hepatitis – 2019 ChinaAbout.net, about US | Cookies Notice | site Map |Privacy policy | 0.158! Species of plant in the genus Sophora of the family Fabaceae Shennong Bencao Jing ( ca the Shennong Bencao (! Human Liver Microsomes ) in SF aqueous extract of a Chinese herbal medicine Sophora flavescens is the primary of! Lung cancer ( NSCLC ) cells ) 1245 350822 p450s by the pregnane X:... Extracts of Sophora flavescens in male and female C57BL/6JNarl mice Intestine and.... Policy |, p.o. activator ( s ) in SF aqueous.! Of eight TCM herbs: Taraxacum campylodes G.E safety and that of our.! Such as eczema and pruritus and Bladder 's wort induces hepatic drug metabolism through of!, p.o. extracts of Sophora flavescens extract and its Prenylated flavonoids in Human Liver....

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